Phoenixin Miners Machine
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- Phoenixin Miners Machine
Neurodegenerative disorders are dreadful diseases that affect millions of people worldwide. Mitochondrial dysfunction is closely associated with the development of neurodegenerative disorders. Phoenixin 20 is a newly discovered neuropeptide with a pleiotropic effect. This study showed that the presence of Phoenixin 20 promoted …
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Phoenixin (PNX), first identified in 2013 by Yosten et al, is a highly conserved, secreted peptide[1]. The two main isoforms of PNX are 14 (PNX-14) and 20 (PNX-20) amino acids long[1].
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Phoenixin-14 is a recently discovered peptide regulating appetite. Interestingly, it is expressed in the gastrointestinal tract; however, its supposed receptor, GPR173, is predominantly found in hypothalamic areas. To date, it is unknown how peripherally secreted phoenixin-14 is able to reach its centrally located receptor. To …
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The novel peptide phoenixin was shown to be involved in several physiological processes ranging from reproduction to food intake. Interest in this protein has steadily increased over the last few years and its known implications have become much broader, playing a role in glucose homeostasis, anxiety, nociception, and pruritus.
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Introduction Neuroinflammation is a key aspect of various injuries and diseases of the central nervous system and brain, including stroke, Alzheimer's, Parkinson's, multiple sclerosis, etc. Phoenixin-14 is a naturally occurring pleiotropic peptide involved in reproduction, anxiety, pain, and other functions. Materials and Methods …
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Phoenixin immunoreactivity in the brain and peripheral tissues In our study, phoenixin peptide was chemically synthesized and the antibody directed against the synthetic peptide was
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In order to determine the developmental profile of phoenixin/smim20 expression, we performed RT-PCR analysis at 3 dpf, 7 dpf, 1 month post-fertilization (mpf), and in the hypothalamus of the adult (Fig. 1, B).The phoenixin/smim20 transcript (predicted size: 214 bp) was detected at 3 dpf a developmental stage when the juvenile fish are …
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Phoenixin-14 (PNX) is a newly identified peptide co-expressed in the hypothalamus with the anorexic and cardioactive Nesfatin-1. Like Nesfatin-1, PNX is able to cross the blood-brain barrier and this suggests a role in peripheral modulation. Preliminary mass spectrography data indicate that, in addi …
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Phoenixin (PNX) is a recently discovered neuropeptide shown to be involved in regulating the reproductive system, anxiety-related behaviors and pain though its receptor is still unknown. PNX-14, one of the endogenous active isoforms, is reported to regulate gonadotropin releasing hormone (GnRH) receptor expression and GnRH secretion. ...
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Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates. In mammals, PNX stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes. Our ...
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In the 8 years since its identification, the peptide phoenixin (PNX) has been linked to numerous physiological processes and possible therapeutic applications [].PNX was discovered by Yosten et al using a bioinformatics algorithm based on data from the Human Genome Project that searched for conserved, secreted peptides [].PNX was …
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Phoenixin 20 is a newly discovered neuropeptide with a pleiotropic effect. This study showed that the presence of Phoenixin 20 promoted neuronal mitochondrial biogenesis in vitro. In cultured neuronal M17 cells, Phoenixin 20 increased the expression of mitochondrial regulators PGC-1α, NRF-1, and TFAM at both mRNA and protein levels.
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Bitcoin mining is the process by which blocks of transactions are added to the public blockchain and verified. It's also the process by which new Bitcoin is created—a mechanism that both secures the integrity of the blockchain and incentivizes participation in the network.. Miners compete to add new blocks to the blockchain. Mining Bitcoin …
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In the 8 years since its identification, the peptide phoenixin (PNX) has been linked to numerous physiological processes and possible therapeutic applications [].PNX was discovered by Yosten et al using a bioinformatics algorithm based on data from the Human Genome Project that searched for conserved, secreted peptides [].PNX was …
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Phoenixin-14 (PNX), initially discovered in the rat hypothalamus, was also detected in dorsal root ganglion (DRG) cells, where its involvement in the regulation of pain and/or itch sensation was suggested. However, there is a lack of data not only on its distribution in DRGs along individual segments of the spinal cord, but also on the …
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Phoenixin (PNX) neuropeptide is a cleaved product of the Smim20 protein. Its most common isoforms are the 14- and 20-amino acid peptides. The biological functions of PNX are mediated via the activation of the GPR173 receptor. PNX plays an important role in the central nervous system (CNS) and in the …
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As a starting point, all miners take the data from the previous block, known as the "block header"– which contains things like a timestamp of the block, the hash of the previous block data ...
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1. Introduction. Phoenixin (PNX) is recently discovered neuropeptide which is produced by proteolytic processing of a small integral membrane protein 20 (SMIM20) [1].Proteolytic cleavage at multiple dibasic sites of the SMIM20 precursor protein yields several isoforms of PNX composed of 42, 36, 26, 20, 17 and 14 amino acids, …
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Phoenixin is novel neuropeptide, recently identified following the description of a peptide sequence highly conserved across several animal species, including humans, cows, and pigs. Expressed both centrally in the hypothalamus and arcuate nucleus and peripherally in cardiac and gastrointestinal tissue, it appears to modulate reproductive ...
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